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Few consistent patterns emerge in comparisons of NSAIDs based upon chance that summary altered odds ratios of acute myocardial infarction which has a offered drug exceeded All those for an additional, besides that rofecoxib is connected to a lot more cardiotoxicity than standard NSAIDs (diclofenac, ibuprofen, and naproxen) and celecoxib (see fig three in Internet appendix 3).
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To examine how imperfect adjustment resulting from systematically lacking confounders could possibly have an affect on estimates of acute myocardial infarction, we employed two adjustment strategies.
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Values on the among study standard deviations on the log odds ratio summarised throughout publicity categories experienced a imply of 0.one hundred as well as a median of 0.108 in the first analysis. To get a given category of NSAID use, the percentages ratios are equivalent in magnitude across research. This means superior robustness In spite of populations remaining heterogeneous and period of drug use and dose being created dependant on differing resources of Uncooked info.
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The similarity of definition and ascertainment of cases and controls in Each and every study see (desk 2 in Website appendix two) confirmed the appropriateness of pooling within a meta-analysis.